A Rare Case of Lupus Vulgaris with Papulonecrotic Tuberculid and Discoid Lupus Erythematosus
نویسندگان
چکیده
To the Editor: A 48‐year‐old woman presented with a plaque on her left helix that had persisted for 20 years, erythemas and scales on both earlobes present for 9 months, and papules on both thighs present for 6 months. Neither she nor her family had any special history. Physical examination revealed a well‐circumscribed, dark‐red plaque on her left helix, and red erythema on both her earlobes, with adherent scales and red papules symmetrically distributed on both thighs with crust and scale [Figure 1a]. Routine examinations showed no abnormal findings. Pathological examination of the left helix showed that the epidermis was thin, with flattening of the rete ridges and many epithelioid granulomas with local caseous necrosis, accompanied by infiltration of lymphocytes into the dermis, multinucleated giant cells were not remarkable [Figure 1b]. In addition, acid‐fast staining yielded negative results. The earlobe biopsy showed epidermal hyperkeratosis and parakeratosis, liquefaction degeneration of the basal cells, and follicular keratotic plugging, and the blood vessels and skin appendages surrounded by lymphocytes in the dermis [Figure 1c]. The thigh biopsy showed epidermal hyperkeratosis and local parakeratosis, and palisading granuloma in the dermis, accompanied by progressive necrosis of the central collagen with mucin deposition [Figure 1d]. A tuberculin (purified protein derivative [PPD]) test performed on the forearm was strongly positive. Polymerase chain reaction for Mycobacterium tuberculosis in both the left helix plaque and the thigh papule was negative. Therefore, a diagnosis of lupus vulgaris was made for the left helix; both earlobes were diagnosed with discoid lupus erythematosus, and both thighs with papulonecrotic tuberculid.
منابع مشابه
A Case Report of Phakomatosis Pigmentovascularis in a Patient with Discoid Lupus Erythematosus and Epidermal Naevus
We report phakomatosis pigmentovascularis (PPV) detected in a 40- year-old male characterized by the presence of a port-wine stain in the background of aberrant Mongolian spots covering the back, nevus of Ota, ocular melanosis, epidermal nevus and a scaly patch with the diagnosis of discoid lupus erytematosus. These associations have not been reported yet.
متن کاملDescriptive study of patients with discoid Lupus Erythematosus referred to Razi Hospital in Tehran in 1377
Background: Discoid lupus erythematosus (DLE) is a variety of lupus disease characterized with sticky thick scaces telangiectasia and follicular plugging. Objectives: To determine the relative frequency of clinical, paraclinical and pathological findings in patients with DLE. Patients and Methods: The clinical, Paraclinical and pathological findings in 50 biopsy proven patients with DLE referre...
متن کاملImmunohistochemistry profile of inflammatory cells in lichen planopilaris and discoid lupus erythematosus
Background: Scarring (cicatricial) alopecia represents a complex group of inflammatory disorders, mainly characterized by destruction of the hair follicle unit. Lichen planopilaris (LPP) and discoid lupus erythematosus (DLE) are the two main causes of primary cicatricial alopecia (PCA), both leading to hair follicle destruction and irreversible alopecia. However, they are different in pathogene...
متن کاملScalp sarcoidosis mimicking discoid lupus erythematosus with lichenoid features in histology
متن کامل
Cutaneous Manifestations of Systemic Lupus Erythematosus in Iranian Children
Systemic lupus erythematous (SLE) is an autoimmune process in which cutaneous lesions occur in majority of patients. This study was conducted to determine the pattern and prevalence of such lesions in SLE in Iranian children infected with SLE. Forty-eight patients, age between 3-16 yrs and male to female ratio of 7/1 were examined for the presence of cutaneous manifestations of SLE. The most co...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 130 شماره
صفحات -
تاریخ انتشار 2017